Paul O'Dette has performed at major international festivals all over the world, including Boston, Los Angeles, Vancouver, Berkeley, Utrecht, London, Bath, Paris, Montpellier, Bremen, Dresden, Munich, Berlin, Frankfurt, Leipzig, Vienna, Prague, Milan, Geneva, Barcelona, Copenhagen, Oslo and Melbourne. Though best known for his recitals and recordings of virtuoso solo lute music, Paul O'Dette maintains an active career as an ensemble musician as well, performing with such artists as Jordi Savall, Gustav Leonhardt, Nikolaus Harnoncourt, William Christie, Christopher Hogwood, Andrew Parrott, Nicholas McGegan, Tafelmusik, The Parley of Instruments and The Harp Consort. He is also a member of Tragicomedia, a continuo ensemble acclaimed for its recordings and concerts of 17th-century operas, cantatas, and oratorios.

To date, Paul has made more than 100 recordings, many of which have been nominated for Gramophone's 'Record of the Year' Award. He has also broadcast for the ABC (Australia), BBC (United Kingdom), CBC (Canada), Radio France, RAI (Italy), Westdeutscher Rundfunk (Cologne), Bayerischer Rundfunk (Munich), SFB (Berlin), NOS (Holland), Austrian Radio, Spanish Radio and Television, TV Ankara, Hungarian Television, Norwegian Radio, Danish Radio and Television, Swedish Television, Swiss Radio and Television, National Public Radio (USA) and CBS Television (USA).

Mr O'Dette has also been active conducting Baroque operas. In 1997, together with Stephen Stubbs, he led performances of Luigi Rossi's L'Orfeo at Tanglewood, the Boston Early Music Festival and the Drottningholm Court Theatre in Sweden, while in 1999 they directed performances of Cavalli's Ercole Amante at the Boston Early Music Festival, Tanglewood, and the Utrecht Early Music Festival and Provenzale's La Stellidaura Vendicata at the Vadstena Academy in Sweden.

In addition to his activities as a performer, Paul O'Dette is an avid researcher, having worked extensively on the performance and sources of 17-century Italian and English solo song, continuo practices and lute technique, the latter resulting in a forthcoming book co-authored by Patrick O'Brien. He has published numerous articles on issues of historical performance practice and co-authored the Dowland entry in the latest update of the New Grove Dictionary of Music and Musicians.

Paul O'Dette has served as Director of Early Music at the Eastman School of Music since 1976 and is Artistic Director of the Boston Early Music Festival.